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Change the way how infection causing microbes are identified based on proprietary algorithms.

Use DISQVER®

What is DISQVER®

DISQVER® is a NGS (next-generation sequencing) based pathogen detection platform by Noscendo integrating a CE-IVD software solution for sensitive, reliable and fast pathogen identification and assessment. DISQVER® allows a hypothesis free detection of bacteria, fungi, DNA viruses and parasites from a single standard blood draw without prior cultivation or knowledge about the aetiology of the infection. DISQVER® uses proprietary and continuously refined databases as well as relevance assessment methods allowing us to make a precise differentiation of commensals, contamination and infection.

Key Facts

Cell-free DNA as new and more abundant biomarker allows precise analysis of the microbial load at the time of blood collection
Detects bacteria, fungi, DNA viruses and parasites from a standard blood sample
Reliably detects difficult and non-cultivatable pathogens
Independent of an already started anti-infective therapy
Without prior cultivation or prior knowledge of the possible cause of infection
Reliable statement on the exclusion of an infection

DISQVER® in a nutshell

1

Blood Sample

Cell-free DNA, as an abundant biomarker, from a standard blood draw is used for pathogen detection

2

Genomics

Data is prepared using highly sensitive genomic workflow on newest sequencing technology

3

Bioinformatics

Advanced proprietary algorithms and continuously refined clinical grade databased are used to analyse sequencing data

4

Report

An analytical report containing all relevant pathogens detected in the patient’s sample is generated and provided to you in real time by the „NOS-Portal“

DISQVER® tailored to your needs

We are here to give you the ability to help patients get the best possible care.

Offering DISQVER® tailored to your needs. We give you an option to use DISQVER® in a direct and easy way: the Send-In model. We are taking care of logistics, analysis and result communication so that you can focus on solving your daily challenges.

Or

We partner with your laboratory to bring DISQVER® even closer to the patient: the Enabling model. Enabling your laboratory to offer DISQVER® reduces turn around times, and supports you within your familiar information paths. New, unique ways of pathogen detection embedded in your known environment. Please contact us if you need further information on Noscendo services, or if you are interested to test or implement Noscendo diagnostics in your hospital, so we can set up a service tailored to your needs.

Send-In

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36-42 h

Medical Express - Overnight

Send in Noscendo laboratory

No own sequencing device necessary

Easy to use for small sample numbers

Optimal cost benefit ratio for small sample numbers

Enabling

Contact Us

18-24 h

None

Enabling your own laboratory

Full cost control of the entire lab process

Optimal utilisation of your sequencing device

Embedded into your laboratory environment

Same reliability independent of the used model

Publications & Applications

Whitepapers

Secondary infections in COVID-19 Diseases

COVID-19 infection can cause a number of complications such as hypoxia, acute respirato- ry distress syndrome (ARDS), thromboembolic disease, multi-organ failure and in some ca- ses secondary bloodstream infections. These may be pre-existing (co-infections) or occur during COVID-19 disease (secondary infections). Concomitant microbial infections caused by bacteria, fungi or viruses are common in viral respiratory infections and cause high mor- bidity and mortality.

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Hematooncology

Infections and especially bloodstream infections are a major cause of complications for oncological and haematological patients during or after therapy. They are associated with increased morbidity and mortality. Previous methods for detecting bloodstream infections in these indications have significant disadvantages. The DISQVER® pathogen test offers a solution to fill the gap left by existing tests. With its open-ended approach without hypotheses, the innovative bioinformatics of DISQVER® enables reliable, efficient and rapid identification of pathogens from patient blood. DISQVER® represents a new generation in pathogen diagnostics and enables a completely new perspective in the treatment of bloodstream infections.

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Acute and severe infections

Systemic bloodstream infections, caused by e.g. peritonitis, pneumonia, after organ trans- plantation or even sepsis, are associated with high case numbers, high mortality and enormous costs. The DISQVER® pathogen test offers a solution to close the gap of existing tests. With an open-ended and hypothesis-free approach, DISQVER® with its combination of NGS and innovative bioinformatics enables reliable, efficient and rapid identification of pathogens from patient blood. DISQVER® represents a new generation of pathogen diagnostics and enables a completely new perspective in the treatment of bloodstream infections.

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