Complete knowledge in one
single test

Change the way how infection causing microbes are identified based on proprietary algorithms.

Use DISQVER®

What is DISQVER®

DISQVER® is a NGS (next-generation sequencing) based pathogen detection platform by Noscendo integrating a CE-IVD software solution for sensitive, reliable and fast pathogen identification and assessment. DISQVER® allows a hypothesis free detection of bacteria, fungi, DNA viruses and parasites from a single standard blood draw without prior cultivation or knowledge about the aetiology of the infection. DISQVER® uses proprietary and continuously refined databases as well as relevance assessment methods allowing us to make a precise differentiation of commensals, contamination and infection.

Key Facts

Cell-free DNA as new and more abundant biomarker allows precise analysis of the microbial load at the time of blood collection
Detects bacteria, fungi, DNA viruses and parasites from a standard blood sample
Reliably detects difficult and non-cultivatable pathogens
Independent of an already started anti-infective therapy
Without prior cultivation or prior knowledge of the possible cause of infection
Reliable statement on the exclusion of an infection

DISQVER® in a nutshell

1

Blood Sample

Cell-free DNA, as an abundant biomarker, from a standard blood draw is used for pathogen detection

2

Genomics

Data is prepared using highly sensitive genomic workflow on newest sequencing technology

3

Bioinformatics

Advanced proprietary algorithms and continuously refined clinical grade databased are used to analyse sequencing data

4

Report

An analytical report containing all relevant pathogens detected in the patient’s sample is generated and provided to you in real time by the „NOS-Portal“

DISQVER® tailored to your needs

We are here to give you the ability to help patients get the best possible care.

Offering DISQVER® tailored to your needs. We give you an option to use DISQVER® in a direct and easy way: the Send-In model. We are taking care of logistics, analysis and result communication so that you can focus on solving your daily challenges.

Or

We partner with your laboratory to bring DISQVER® even closer to the patient: the Enabling model. Enabling your laboratory to offer DISQVER® reduces turn around times, and supports you within your familiar information paths. New, unique ways of pathogen detection embedded in your known environment. Please contact us if you need further information on Noscendo services, or if you are interested to test or implement Noscendo diagnostics in your hospital, so we can set up a service tailored to your needs.

Send-In

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36-42 h

Medical Express - Overnight

Send in Noscendo laboratory

No own sequencing device necessary

Easy to use for small sample numbers

Optimal cost benefit ratio for small sample numbers

Enabling

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18-24 h

None

Enabling your own laboratory

Full cost control of the entire lab process

Optimal utilisation of your sequencing device

Embedded into your laboratory environment

Same reliability independent of the used model

Publications & Applications

Clinical Study Grumaz et al.

Next-generation sequencing diagnostics of bacteremia in septic patients

JGenome Med. 2016 Dezember. doi: 10.1186/s13073-016-0326-8

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Clinical Study Decker et al.

Immune-Response Patterns and Next Generation Sequencing Diagnostics for the Detection of Mycoses in Patients with Septic Shock—Results of a Combined Clinical and Experimental Investigation

Int. J. Mol. Sci. 2017 August. doi: 10.3390/ijms18081796

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Clinical Study Decker et al.

New approaches for the detection of invasive fungal diseases in patients following liver transplantation—results of an observational clinical pilot study

Langenbecks Arch. Surg. 2019 May. doi: 10.1007/s00423-019-01769-y

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Clinical Study Grumaz et al.

Enhanced Performance of Next-Generation Sequencing Diagnostics Compared With Standard of Care Microbiological Diagnostics in Patients Suffering From Septic Shock

Crit. Care Med. 2019 May. doi: 10.1097/CCM.0000000000003658

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Study Protocol Brenner et al.

Next-generation sequencing diagnostics of bacteremia in sepsis (Next GeneSiS-Trial): Study protocol of a prospective, observational, noninterventional, multicenter, clinical trial

Medicine (Baltimore) 2018 February. doi: 10.1097/MD.0000000000009868

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Clinical Study Grumaz, C. et al.

Rapid Next-Generation Sequencing–Based Diagnostics of Bacteremia in Septic Patients

J MOL DIAGN 2020 March. doi: 1https://doi.org/10.1016/j.jmoldx.2019.12.006

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Whitepaper Noscendo

Pilot Phase 2019

Business Paper 2019 July

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Whitepaper Noscendo

Pilot Phase 2019: Oncology

Business Paper 2019 July

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Whitepaper Noscendo

Pilot Phase 2019: Acute and Severe Infections

Business Paper 2019 July

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